Titolo progetto: New perspectives in proteolysis-mediated mechanism of transthyretin related amyloidosis: the role of mechanic forces

Programma di finanziamento: Pfizer Global Medical Grants

Responsabile scientifico: prof.ssa Cristina Cantarutti

Ruolo del DAME: proponente unico

Descrizione generale:

The project aims at elucidating the role of mechanical forces in the proteolytic event that leads to protein aggregation. It wants to understand if and how mechanical forces can modulate protein dynamics promoting a shift towards less stable states more susceptible to proteolytic cleavage.

Date inizio e fine progetto: 05.11.2022 – 15.04.2025

Budget totale del progetto: 146.131,45,00€

Link: www.pfizer.com