Titolo progetto: AIRC 2017 - Unveiling the role of Ape1 in regulating tumor cell resistance to chemotherapy through miRNAs processing in HCC and NSCL

Programma di finanziamento: Bando AIRC 2017

Responsabile scientifico: prof. Gianluca Tell

Collaboratori: dott.ssa Giulia Antoniali

Ruolo del DAME: proponente unico

Descrizione generale:

This project will significantly implement current translational approaches for the combination cancer therapies based on Ape1 targeting, providing new insights in the basic principles of the non-canonical functions of BER regulatory mechanisms in tumors.

The Ape1 miRNA processing activity may be associated with cancer development and chemoresistance through specific gene alterations. In the previous AIRC project (IG-14038), using HeLa cells, we unexpectedly found a number of miRNAs directly regulated by Ape1 under genotoxic stress conditions, suggesting its contribution in post-transcriptional gene regulation through miRNA-processing/decay. We found some Ape1 cancer variants with altered protein interaction abilities and causing persistent genomic instability. Better knowledge of Ape1's roles in miRNA metabolism represents the basis to powerful strategies for cancer combination therapy impairing the Ape1 network.

Date inizio e fine progetto: 02.01.2018 – 01.01.2023

Budget totale del progetto: 454.850,00€

Contatti: Gianluca Tell