Titolo progetto: Inactivity induced neuromuscular impairment through different ages: from children, to young and middle age adults (InactivAge)

Programma di finanziamento: PRIN 2020

Responsabile scientifico: prof. Bruno Grassi

Collaboratori: prof. Stefano Lazzer

Ruolo del DAME: partner

Descrizione generale:

Inactivity causes 5 million deaths per year [58]. It can be considered a pandemic [43,58], decreasing exercise tolerance and dramatically increasing disease risks [9]. The major phenomena occur at the level of muscle (loss of mass and strength), nervous system (impairment in central and peripheral motor control) and metabolism (impaired oxidative metabolism and insulin resistance)[9]. Most previous studies focused on muscle only and on elderly people. Few studies addressed the interactions between muscle and neural control, through sensorimotor loops and neuromuscular junctions (NMJ), in causing exercise intolerance and whole-body metabolic impairment and the underlying mechanisms. Inactivity affects all ages. Little is known on the impact of inactivity on developing motor systems in children and on their integrity and function in middle age (55-65) adults. The recent COVID-19 outbreak has induced inactivity in millions of people, of all ages worldwide [55] and stressed its detrimental consequences.

Partner del progetto:

• Università degli Studi di Pavia, Dipartimento di Medicina Molecolare
• Università degli Studi di Padova, Dipartimento di Scienze Biomediche
• Università degli Studi di Roma Tor Vergata, Dipartimento di Fisiologia Neuromotoria, Istituto Scientifico Fondazione Santa Lucia
• Università degli Studi di Udine, Dipartimento di Area Medica

Date inizio e fine progetto: 08.05.2022 – 07.05.2025

Budget totale del progetto: 262.881,00€

Sito web: prin.mur.gov.it